news & publications

Structural Biology

E. Y. Chien, W. Liu, Q. Zhao, V. Katritch, G. W. Han, M. A. Hanson, L. Shi, A. H. Newman, J. A. Javitch, V. Cherezov and R. C. Stevens (2010) Structure of the human dopamine D3 receptor in complex with a D2/D3 selective antagonist. Science 330: 1091-5 (2010)
Hanson, M.A., and R.C. Stevens. "Discovery of new GPCR biology: One receptor structure at a time." Structure 17, 8-14 (2009). .
Michino, M., E. Abola, GPCR Assessment Participants, C.L. Brooks, J.S. Dixon, J. Moult, and R.C. Stevens. "Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008." Nature Rev. Drug Disc. 8, 455-463 (2009).
Hanson, M.A., V. Cherezov, C.B. Roth, M.T. Griffith, V.-P. Jaakola, E.Y.T. Chien, J. Velasquez, P. Kuhn, and R.C. Stevens "A specific cholesterol binding site is established by the 2.8 Å structure of the human β2-adrenergic receptor" Structure, 16, 897-905 (2008).
Roth, C.B., M.A. Hanson, and R.C. Stevens "Stabilization of the human β2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu-1223.41, A critical residue in GPCR structure" J. Mol. Biol. 376, 1305-1319 (2008).
Jaakola,V.P., M.T. Griffith, M.A. Hanson, V. Cherezov, E.Y.T. Chien, J.R. Lane, A.P. Ijzerman, and R.C. Stevens. The 2.6Å crystal structure of a human A2A adenosine receptor bound to an antagonist. Science. 322, 1211-1217 (2008).
Cherezov, V., D.M. Rosenbaum, M.A. Hanson, S.G.F. Rasmussen, F.S. Thian, T.S. Kobilka, H.-J. Choi, P. Kuhn, W.I. Weis, B.K. Kobilka, and R.C. Stevens "High resolution crystal structure of human β2-adrenergic G protein coupled receptor" Science 318, 1258-1265 (2007).
Rosenbaum, D.M., V. Cherezov, M.A. Hanson, S.G.F. Rasmussen, F.S. Thian, T.S. Kobilka, H.-J. Choi, X.-J. Yao, W.I. Weis, R.C. Stevens, and B.K. Kobilka "GPCR engineering provides high resolution structural insights into the function of the β2-adrenergic receptor" Science 318, 1266-1273 (2007).